Resmetirom can cause adverse reactions ranging from relatively common gastrointestinal symptoms to potentially serious liver and gallbladder complications. The frequency and severity can vary among patients.
Common adverse reactions
Current U.S. labeling identifies the following adverse reactions as occurring in at least 5% of patients and more often than placebo:
- Diarrhea
- Nausea
- Pruritus
- Vomiting
- Constipation
- Abdominal pain
- Dizziness
The EMA likewise identifies diarrhea and nausea among the most common adverse effects.
Important serious risks
| Risk | Why it matters |
|---|---|
| Hepatotoxicity | Liver injury can occur |
| Gallbladder-related events | Cholelithiasis and cholecystitis have been reported |
| Drug interactions | Resmetirom can affect or be affected by several medicines |
Warning signs
Patients should promptly discuss concerning symptoms with their healthcare professional. Symptoms such as jaundice, dark urine, significant abdominal pain, persistent vomiting or other signs of liver or gallbladder disease may require medical evaluation.
Monitoring
Clinical assessment may include liver-related symptoms and laboratory testing. The appropriate monitoring schedule depends on the patient’s clinical circumstances.